Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3R-IN-1 Hydrochloride 是一种有效的组胺H3受体 (H3R) 的反向激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 11,100 | 10-14周 | ||
50 mg | ¥ 14,500 | 10-14周 | ||
100 mg | ¥ 22,800 | 10-14周 |
产品描述 | H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) . |
体外活性 | Treatment with H3R-IN-1, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC 50 =25 nM. Western blot shows a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R-IN-1, which reveals that treatment with H3R-IN-1 drives more OPCs to differentiate. H3R-IN-1 increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner [1]. |
体内活性 | The ability of H3R-IN-1 to enhance remyelination in vivo is determined using the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group [1]. |
分子量 | 377.87 |
分子式 | C19H24ClN3O3 |
CAS No. | 2319790-07-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (66.16 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6464 mL | 13.2321 mL | 26.4641 mL | 66.1603 mL |
5 mM | 0.5293 mL | 2.6464 mL | 5.2928 mL | 13.2321 mL | |
10 mM | 0.2646 mL | 1.3232 mL | 2.6464 mL | 6.616 mL | |
20 mM | 0.1323 mL | 0.6616 mL | 1.3232 mL | 3.308 mL | |
50 mM | 0.0529 mL | 0.2646 mL | 0.5293 mL | 1.3232 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
H3R-IN-1 Hydrochloride 2319790-07-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor H3RIN1 Hydrochloride H3R IN 1 Hydrochloride H-3R-IN-1 Hydrochloride Inhibitor inhibitor inhibit